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Research Associate Viral Vector Process Development

Company: Atara Biotherapeutics, Inc.
Location: Thousand Oaks
Posted on: February 25, 2021

Job Description:

Research Associate/ Sr. Research Associate Viral Vector Process Development The Viral Vector Process Development Research Associate/Sr.--Research Associate is an active member of a growing viral vector process development team supporting Atara's T-cell therapy programs.-- The individual will contribute to the development, scale up and technology transfer of the viral vector production with focus on cell culture development and scale-up. These activities can include aseptic cell culture of viral vector suspension and/or adherent cell lines, scale-down model and qualification, scale-up development, process optimization, robustness studies, and process characterization. Experience with both suspension and adherent formats are desired. This position includes viral seed stock production, viral vector production and purification, virus process development and scale-up, and analytical testing of in-process controls. Reports to:--Principal Scientist--Viral Vector Development Work Location:--Thousand Oaks (northwest Los Angeles area), CA.--

Primary Responsibilities:

  • Hands-on work in the executing study protocols, assisting in optimizing upstream (cell culture, scale-up, characterization) and downstream (clarification, chromatography, tangential flow filtration) unit operations for viral vector production
  • Support technology transfer into vector manufacturing as required
  • Works closely with external partners on appropriate viral vector process and characterization studies to enable manufacturing
  • Supports virus analytical method development, qualification, transfer, and associated protocols/reports as needed
  • Assists with viral vector product quality attribute assessment and scoring to identify critical quality attributes (CQA)
  • Supports viral vector process and analytical sections for regulatory filings and response to questions Travel: Ability to travel up to 15-20% Qualifications Education and Experience
    • Bachelors degree with 1+ years of related industry experience
    • Knowledge and experience in viral vector production, purification, and analytics
    • Proficient with large-scale mammalian cell culture and suspension cells
    • Ability to design experiments, follow procedures with attention to detail, and successfully execute experiments at the bench
    • Project-management skills and ability to work successfully with contracting laboratories and manufacturing facilities
    • Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities
    • Demonstrated ability to maintain detailed execution records and perform data analysis More About Atara Bio We launched--Atara Biotherapeutics--in August 2012 to help patients with serious diseases and few therapeutic options. We're named after Atara Ciechanover who suffered from cancer before passing away. We are considered a leading off-the-shelf T-cell immunotherapy company (Nasdaq--ATRA) developing novel treatments for patients with cancer, autoimmune and viral diseases. We're proud of our team of 350+ Atarians co-located by design in South San Francisco (corporate headquarters) and Southern California (R&D and manufacturing headquarters in the northwest Los Angeles area) with a newly-established European headquarters in Zug, Switzerland. Atara also has a R&D site in the Denver, Colorado area and an office in New York City. Our Southern California hub is anchored by a new 90,000 sq. ft., state-of-the-art Atara T-Cell Operations and Manufacturing (ATOM) facility in Thousand Oaks, California.

      Our mission - "Transform the lives of patients with serious medical conditions through pioneering science, teamwork, and a commitment to excellence." Our vision - "T-Cell Immunotherapy for every patient, any time." Visit www.atarabio.com to learn more.

      Atara Bio is an equal opportunity employer and makes employment decisions on the basis of merit and other lawful factors. In accordance with applicable law, the Company prohibits discrimination based on race, color, religion, creed, sex, gender (including pregnancy, childbirth or medical condition related to pregnancy or childbirth), gender identity, expression or dysphoria, marital status, age, national origin or ancestry, physical or mental disability, medical condition, genetic information, veteran status, caregiver status, sexual orientation, transgender status or any other classification protected by federal, state or local laws or because of the individual's association with a member of a protected group or connection to an organization or group related to a protected group.

      We comply with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Atara Bio in the United States. Thousand Oaks, California Research Associate/ Sr. Research Associate Viral Vector Process Development

Keywords: Atara Biotherapeutics, Inc., Thousand Oaks , Research Associate Viral Vector Process Development, Other , Thousand Oaks, California

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