Senior Scientist - IPP Structural Biology

Company: Amgen SA
Location: Thousand Oaks
Posted on: September 17, 2023

Job Description:

HOW MIGHT YOU DEFY IMAGINATION?You've worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.Senior Scientist - IPP Structural BiologyLiveWhat you will doLet's do this. Let's change the world. In this vital role you will join the Structural Biology Department at our site in Thousand Oaks, CA. The Structural Biology laboratory provides comprehensive molecular insights and structure-based design for drug-target assessment, mechanism of action, protein-protein and protein-ligand interactions, as well as protein engineering to facilitate drug discovery across various therapeutic areas.Responsibilities:

• Responsible for structure determination of target molecules in our small molecule induced proximity platform (IPP) using X-ray crystallography and/or cryo-electron microscopy (cryo-EM).
• Work closely with molecular biologists and protein biochemists in the protein expression group.
• Interact directly with small molecule scientists including computational scientists, medicinal chemists, and protein engineers.
• Must be flexible to apply their knowledge to new areas of study, with strong interpersonal and communication skills to thrive in a highly collaborative environment.WinWhat we expect of youWe are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a driven individual with these qualifications.Basic Qualifications:
  • Doctorate Degree or
  • Master's degree and 4 years of structural biology and general biochemistry experience or
  • Bachelor's degree and 6 years of structural biology and general biochemistry experiencePreferred Qualifications:
    • Ph.D. with a deep understanding of structural biology and general biochemistry
    • At least 2 years of postdoctoral research experience in large macromolecular complex structure determination. Knowledge of state-of-the-art protein structural biology techniques including all aspects of construct design, expression, purification, characterization, structure determination and analysis
    • Proven expertise on protein crystallography and/or cryo-EM single particle analysis, to determine atomic resolution structures
    • Experience with ubiquitin-proteasome system for protein degradation
    • Excellent presentation skills (written and oral) for effective team-based communication of results.
    • Ability to work independently and effectively within timelines and to collaborate in a multidisciplinary environment.
    • Skills in managing multiple projects and capability to prioritize.
    • Experience with other protein biochemical and/or biophysical characterization of protein complexesThriveWhat you can expect of usAs we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being.The annual base salary range for this opportunity in the U.S. is $120,669-144,385.In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:
      • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
      • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
      • Stock-based long-term incentives
      • Award-winning time-off plans and bi-annual company-wide shutdowns
      • Flexible work models, including remote work arrangements, where possibleApply nowfor a career that defies imaginationObjects in your future are closer than they appear. Join us.careers.amgen.comAmgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancers, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Keywords: Amgen SA, Thousand Oaks , Senior Scientist - IPP Structural Biology, Other , Thousand Oaks, California